反应详情

To a solution of NaOEt (from 0.68 g of sodium) in ethanol (20 ml) was added 2,3,5-trichlorophenylacetonitrile (5 g) and ethyl acetate (4.43 ml). The mixture was heated under reflux, under nitrogen for 2.5 hours. The mixture was left standing at room temperature overnight. The mixture was then concentrated and the residue was dissolved in water. The aqueous phase was washed with ether, acidified with concentrated H2SO4 and extracted with ether. The extracts were bulked, dried (MgSO4) and evaporated, 2.59 g, mp. 134°-135° C.

1. temperatureThe mixture was heated
2. temperatureunder reflux, under nitrogen for 2.5 hours
3. waitThe mixture was left
4. concentrationThe mixture was then concentrated
5. dissolutionthe residue was dissolved in water
6. washThe aqueous phase was washed with ether
7. extractionextracted with ether
8. dry with materialdried (MgSO4)
9. customevaporated