Methanol → 2-chloro-N-{1-[(methanesulfonylcarbamoyl)methyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl}-6H-thieno[2,3-b]pyrrole-5-carboxamide

HRID 2326198Notes

Reaction equation

HRID 2326198 reaction equation
[C:17](=[O:18])([OH:19])[CH2:20][N:21]1[C:22](=[O:43])[CH:23]([NH:31][C:32](=[O:33])[c:34]2[cH:35][c:36]3[c:37]([nH:38]2)[s:39][c:40]([Cl:42])[cH:41]3)[CH2:24][c:25]2[cH:26][cH:27][cH:28][cH:29][c:30]21.[CH3:1][S:2](=[O:3])(=[O:4])[NH2:5].[CH3:44][CH2:45][O:46][CH2:47][CH3:48].[CH3:49][N:50]([CH3:51])[c:52]1[cH:53][cH:54][n:55][cH:56][cH:57]1.[CH3:61][OH:62].[CH3:6][CH2:7][N:8]=[C:9]=[N:10][CH2:11][CH2:12][CH2:13][N:14]([CH3:15])[CH3:16].[Cl:58][CH2:59][Cl:60].[Cl:63][CH2:64][Cl:65]>>[CH3:1][S:2](=[O:3])(=[O:4])[NH:5][C:17](=[O:18])[CH2:20][N:21]1[C:22](=[O:43])[CH:23]([NH:31][C:32](=[O:33])[c:34]2[cH:35][c:36]3[c:37]([nH:38]2)[s:39][c:40]([Cl:42])[cH:41]3)[CH2:24][c:25]2[cH:26][cH:27][cH:28][cH:29][c:30]21

Participants

8

Reactant 7

HCID 887MethanolHCID 3283Diethyl EtherHCID 6344Dichloromethane2×HCID 142844-(Dimethylamino)pyridineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 72879MethanesulfonamideHCID 10319016N-[1-(Carboxymethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-2-chloro-6H-thieno[2,3-b]pyrrole-5-carboxamide

Product 1

HCID 104129102-chloro-N-{1-[(methanesulfonylcarbamoyl)methyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl}-6H-thieno[2,3-b]pyrrole-5-carboxamide

Sources & evidence

ORD record
ord-a7eaaaaff61c4a2993ecdce181df8540
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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