HCID 19705062, compound → HCID 19705100, compound

HRID 232625Notes

Reaction equation

HRID 232625 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[C:13]([N+:15]([O-])=O)[C:12]([Cl:18])=[CH:11][C:10]=2[Cl:19])=[C:4]([CH3:20])[N:3]=1>C(O)(=O)C.O=[Pt]=O.C(OCC)(=O)C>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[C:13]([NH2:15])[C:12]([Cl:18])=[CH:11][C:10]=2[Cl:19])=[C:4]([CH3:20])[N:3]=1

Participants

5

Reactant 1

HCID 19705062HCID 19705062, compound

Product 1

HCID 19705100HCID 19705100, compound

Reagents, catalysts & solvents 3

HCID 345198Adams' catalystCatalystHCID 176Acetic AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

2,4-diamino-5-(2,4-dichloro-5-nitrophenyl)-6-methylpyrimidine (4.80 g, 15mmol) was dissolved in glacial acetic acid (18 ml). This solution and 10 mg of Adam's catalyst was stirred under an atmosphere of hydrogen at room temperature for 4 hours. The catalyst was filtered off and the acetic acid was evaporated. The colourless liquid obtained was dissolved in ethyl acetate and washed 3 times with water. After evaporating the ethyl acetate, a white solid was obtained (2.64 g, 9 mmol).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe acetic acid was evaporated
  3. customThe colourless liquid obtained
  4. washwashed 3 times with water
  5. customAfter evaporating the ethyl acetate
  6. customa white solid was obtained (2.64 g, 9 mmol)

Sources & evidence

ORD record
ord-b1cc97c191a647078e19e22d0bca081a
Source dataset
uspto-grants-1997_01
Patent number
US05591746

Reaction notes

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