Dimethylformamide → 2,2-dimethyl-5-[4-methyl-1-[2-methyl-4-[4-(trifluoromethyl)-2-pyridinyl]piperazin-1-yl]-1-oxopentan-2-yl]-1,3-dioxolan-4-one

HRID 2326701Notes

Reaction equation

HRID 2326701 reaction equation
[CH3:1][C:2]1([CH3:27])[O:3][C:4](=[O:26])[CH:5]([CH:7]([C:8]([O:10][c:9]2[c:11]([F:12])[c:13]([F:14])[c:15]([F:16])[c:17]([F:18])[c:19]2[F:20])=[O:21])[CH2:22][CH:23]([CH3:24])[CH3:25])[O:6]1.[CH3:53][CH2:54][N:55]([CH2:56][CH3:57])[CH2:58][CH3:59].[CH3:60][CH:61]1[CH2:62][N:63]([c:67]2[n:68][cH:69][cH:70][c:71]([C:73]([F:74])([F:75])[F:76])[cH:72]2)[CH2:64][CH2:65][NH:66]1.[O:77]=[CH:78][N:79]([CH3:80])[CH3:81].[OH:28][NH:29][C:30](=[O:31])[CH:32]([OH:33])[CH:34]([C:35]([N:36]1[CH2:37][CH2:38][N:39]([c:40]2[cH:41][cH:42][cH:43][cH:44][n:45]2)[CH2:46][CH2:47]1)=[O:48])[CH2:49][CH:50]([CH3:51])[CH3:52]>>[CH3:1][C:2]1([CH3:27])[O:3][C:4](=[O:26])[CH:5]([CH:7]([C:8](=[O:10])[N:66]2[CH:61]([CH3:60])[CH2:62][N:63]([c:67]3[n:68][cH:69][cH:70][c:71]([C:73]([F:74])([F:75])[F:76])[cH:72]3)[CH2:64][CH2:65]2)[CH2:22][CH:23]([CH3:24])[CH3:25])[O:6]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 663298313-Methyl-1-[4-(trifluoromethyl)-2-pyridinyl]piperazineHCID 72807234(2,3,4,5,6-Pentafluorophenyl) 2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)-4-methylpentanoateHCID 72983429N,2-dihydroxy-5-methyl-3-(4-pyridin-2-ylpiperazine-1-carbonyl)hexanamide

Product 1

HCID 1784451142,2-dimethyl-5-[4-methyl-1-[2-methyl-4-[4-(trifluoromethyl)-2-pyridinyl]piperazin-1-yl]-1-oxopentan-2-yl]-1,3-dioxolan-4-one

Sources & evidence

ORD record
ord-94a6a704386e47318c4fd40ac77435ab
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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