p-Toluenesulfonic acid → Ethyl 2-ethyl-3,4,5,6-tetrafluorobenzoylacetate

HRID 232673Notes

Reaction equation

HRID 232673 reaction equation
[CH2:1]([C:3]1[C:21]([F:22])=[C:20]([F:23])[C:19]([F:24])=[C:18]([F:25])[C:4]=1[C:5]([CH:7](C(OCC)=O)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6])[CH3:2].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[CH2:1]([C:3]1[C:21]([F:22])=[C:20]([F:23])[C:19]([F:24])=[C:18]([F:25])[C:4]=1[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6])[CH3:2]

Participants

3

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 54490655HCID 54490655, compound

Product 1

HCID 53931173Ethyl 2-ethyl-3,4,5,6-tetrafluorobenzoylacetateYield 80.4%

Procedure

Employing diethyl 2-ethyl-3,4,5,6-tetrafluoro-benzoylmalonate (17.2 g) and p-toluenesulfonic acid (0.25 g), the procedure of Reference Example 19 is repeated to give ethyl 2-ethyl-3,4,5,6-tetrafluorobenzoylacetate (11.09 g).

Sources & evidence

ORD record
ord-d3b857d666c54dab89f305cc690291b1
Source dataset
uspto-grants-1997_01
Patent number
US05591744

Reaction notes

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