Tetrahydrofuran → (5-amino-7-bromo-3-chloro-1-fluoro-5H-chromeno[2,3-c]pyridin-5-yl)methanol

HRID 2326786Notes

Reaction equation

HRID 2326786 reaction equation
[Al+3:24].[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[H-:23].[H-:26].[H-:27].[H-:28].[Li+:25].[N:1](=[N+:2]=[N-:3])[C:4]1([CH2:21][OH:22])[c:5]2[cH:6][c:7]([Br:20])[cH:8][cH:9][c:10]2[O:11][c:12]2[c:13]([F:19])[n:14][c:15]([Cl:18])[cH:16][c:17]21>>[NH2:1][C:4]1([CH2:21][OH:22])[c:5]2[cH:6][c:7]([Br:20])[cH:8][cH:9][c:10]2[O:11][c:12]2[c:13]([F:19])[n:14][c:15]([Cl:18])[cH:16][c:17]21

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 86658369(5-azido-7-bromo-3-chloro-1-fluoro-5H-chromeno[2,3-c]pyridin-5-yl)methanol

Product 1

HCID 86658370(5-amino-7-bromo-3-chloro-1-fluoro-5H-chromeno[2,3-c]pyridin-5-yl)methanol

Sources & evidence

ORD record
ord-86a0ffe9f9a54d7ab7b2fad7817dbc03
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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