Ethyl Acetate → 4-[4-Amino-5-(3-fluoro-4-methoxybenzoyl)thiazol-2-ylamino]piperidine-1-sulfonic acid dimethylamide

HRID 2326821Notes

Reaction equation

HRID 2326821 reaction equation
[CH3:25][N:26]([S:27](=[O:28])(=[O:29])[Cl:30])[CH3:31].[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46].[CH:32]([N:33]([CH:34]([CH3:35])[CH3:36])[CH2:37][CH3:38])([CH3:39])[CH3:40].[NH2:1][c:2]1[n:3][c:4]([NH:18][CH:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)[s:5][c:6]1[C:7](=[O:8])[c:9]1[cH:10][c:11]([F:17])[c:12]([O:15][CH3:16])[cH:13][cH:14]1>>[NH2:1][c:2]1[n:3][c:4]([NH:18][CH:19]2[CH2:20][CH2:21][N:22]([S:27]([N:26]([CH3:25])[CH3:31])(=[O:28])=[O:29])[CH2:23][CH2:24]2)[s:5][c:6]1[C:7](=[O:8])[c:9]1[cH:10][c:11]([F:17])[c:12]([O:15][CH3:16])[cH:13][cH:14]1

Participants

5

Reactant 4

HCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 83372Dimethylsulphamoyl chlorideHCID 11951612[4-Amino-2-(piperidin-4-ylamino)thiazol-5-yl]-(3-fluoro-4-methoxyphenyl)methanone

Product 1

HCID 119517954-[4-Amino-5-(3-fluoro-4-methoxybenzoyl)thiazol-2-ylamino]piperidine-1-sulfonic acid dimethylamide

Sources & evidence

ORD record
ord-304d2fc1ba7c48c48cfea08b3559cacc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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