Trifluoroacetic acid → 7'-fluoro-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

HRID 2328010Notes

Reaction equation

HRID 2328010 reaction equation
[CH2:37]([SiH:38]([CH2:39][CH3:40])[CH2:41][CH3:42])[CH3:43].[OH:44][C:45]([C:46]([F:47])([F:48])[F:49])=[O:50].[c:1]1([CH:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:31]2)[N:8]2[C:9](=[O:30])[C:10]3([CH2:11][O:12][c:13]4[cH:14][c:15]5[c:16]([cH:21][c:22]43)[O:17][CH2:18][CH2:19][O:20]5)[c:23]3[cH:24][cH:25][cH:26][c:27]([F:29])[c:28]32)[cH:32][cH:33][cH:34][cH:35][cH:36]1>>[NH:8]1[C:9](=[O:30])[C:10]2([CH2:11][O:12][c:13]3[cH:14][c:15]4[c:16]([cH:21][c:22]32)[O:17][CH2:18][CH2:19][O:20]4)[c:23]2[cH:24][cH:25][cH:26][c:27]([F:29])[c:28]21

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 593522481'-(diphenylmethyl)-7'-fluoro-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

Product 1

HCID 593525427'-fluoro-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-e452681dec4a45509800d1b46a77940c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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