Formaldehyde → HCID 178515526, compound

HRID 232816Notes

Reaction equation

HRID 232816 reaction equation
[C:1]1([C:7]2[NH:8][CH:9]=[CH:10][N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[OH:22].[CH2:23]=O>C(O)(C)C>[C:1]1([C:7]2[NH:11][CH:10]=[C:9]([CH2:23][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:15]=[CH:14][C:13]=3[OH:22])[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 86632-NaphtholHCID 695912-Phenylimidazole

Product 1

HCID 178515526HCID 178515526, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a 30% solution of 2-phenylimidazole (144 g, 1 mole) and 2-naphthol (144 g, 1 mole) in isopropanol, formaline (37% aqueous solution, 1 mole of CH2O) is added over a period of 30 minutes at room temperature, followed by six hours of refluxing at 82°-84° C. The product (270 g of a white powder) is obtained in a yield of 90%.

Workup

  1. temperatureof refluxing at 82°-84° C

Sources & evidence

ORD record
ord-4300397d2c3d42bd8e28b50bc6d34814
Source dataset
uspto-grants-1997_01
Patent number
US05591811

Reaction notes

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