Dimethylformamide → 2-(3-cyano-4-(2-fluoropyridin-4-yl)phenyl)-N-(5-(pyridazin-3-yl)pyridin-2-yl)acetamide

HRID 2328248Notes

Reaction equation

HRID 2328248 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][c:5]([CH2:16][C:17](=[O:18])[OH:19])[cH:6][cH:7][c:8]1-[c:9]1[cH:10][c:11]([F:15])[n:12][cH:13][cH:14]1.[CH:33]([N:34]([CH2:35][CH3:36])[CH:37]([CH3:38])[CH3:39])([CH3:40])[CH3:41].[O:66]=[CH:67][N:68]([CH3:69])[CH3:70].[P-:42]([F:43])([F:44])([F:45])([F:46])([F:47])[F:48].[n:20]1[n:21][c:22](-[c:26]2[cH:27][cH:28][c:29]([NH2:32])[n:30][cH:31]2)[cH:23][cH:24][cH:25]1.[n:49]1([O:50][C:51]([N:52]([CH3:53])[CH3:54])=[N+:55]([CH3:56])[CH3:57])[c:58]2[n:59][cH:60][cH:61][cH:62][c:63]2[n:64][n:65]1>>[C:1](#[N:2])[c:3]1[cH:4][c:5]([CH2:16][C:17](=[O:19])[NH:32][c:29]2[cH:28][cH:27][c:26](-[c:22]3[n:21][n:20][cH:25][cH:24][cH:23]3)[cH:31][n:30]2)[cH:6][cH:7][c:8]1-[c:9]1[cH:10][c:11]([F:15])[n:12][cH:13][cH:14]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 584476635-(Pyridazin-3-yl)pyridin-2-amineHCID 68247400HCID 68247400, compound

Product 1

HCID 584478422-(3-cyano-4-(2-fluoropyridin-4-yl)phenyl)-N-(5-(pyridazin-3-yl)pyridin-2-yl)acetamide

Sources & evidence

ORD record
ord-d439a8fc621145f6b2aaf020754ca22d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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