Tetrahydrofuran → N-Cbz-{4-[7-methoxy-8-methyl-2-(4-trifluoromethyl-thiazol-2-yl)-quinolin-4-yloxy]}-piperidine-2-carboxylic acid methyl ester
Reaction equation
[CH2:78]1[O:79][CH2:80][CH2:81][CH2:82]1.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([OH:23])[cH:8][c:9](-[c:14]3[s:15][cH:16][c:17]([C:19]([F:20])([F:21])[F:22])[n:18]3)[n:10][c:11]2[c:12]1[CH3:13].[O:64]=[C:65]([O:66][CH:67]([CH3:68])[CH3:69])[N:70]=[N:71][C:72]([O:73][CH:74]([CH3:75])[CH3:76])=[O:77].[OH:24][CH:25]1[CH2:26][CH:27]([C:41](=[O:42])[O:43][CH3:44])[N:28]([C:31](=[O:32])[O:33][CH2:34][c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[CH2:29][CH2:30]1.[c:45]1([P:46]([c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[cH:59][cH:60][cH:61][cH:62][cH:63]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([O:23][CH:25]3[CH2:26][CH:27]([C:41](=[O:42])[O:43][CH3:44])[N:28]([C:31](=[O:32])[O:33][CH2:34][c:35]4[cH:36][cH:37][cH:38][cH:39][cH:40]4)[CH2:29][CH2:30]3)[cH:8][c:9](-[c:14]3[s:15][cH:16][c:17]([C:19]([F:20])([F:21])[F:22])[n:18]3)[n:10][c:11]2[c:12]1[CH3:13]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-52b47629cc7e4a65b02bda680fa1c453
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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