Acetate → Methyl 3-(4-amino-7-bromo-1,3-dioxoisoindol-5-yl)prop-2-enoate

HRID 2328904Notes

Reaction equation

HRID 2328904 reaction equation
[C:15]([CH:16]=[CH2:17])(=[O:18])[O:19][CH3:20].[C:32]([O-:33])(=[O:34])[CH3:35].[C:37]([O-:38])(=[O:39])[CH3:40].[CH3:21][CH2:22][N:23]([CH2:24][CH3:25])[CH2:26][CH3:27].[CH3:29][C:30]#[N:31].[NH2:1][c:2]1[c:3]2[c:4]([c:10]([Br:14])[cH:11][c:12]1[I:13])[C:5](=[O:6])[NH:7][C:8]2=[O:9].[OH2:28].[Pd+2:36]>>[NH2:1][c:2]1[c:3]2[c:4]([c:10]([Br:14])[cH:11][c:12]1[CH:17]=[CH:16][C:15](=[O:18])[O:19][CH3:20])[C:5](=[O:6])[NH:7][C:8]2=[O:9]

Participants

8

Reactant 7

HCID 175Acetate2×HCID 962WaterHCID 6342AcetonitrileHCID 7294Methyl AcrylateHCID 8471TriethylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 684887173-Amino-4-iodo-6-bromophthalimide

Product 1

HCID 68491787Methyl 3-(4-amino-7-bromo-1,3-dioxoisoindol-5-yl)prop-2-enoate

Sources & evidence

ORD record
ord-c77019020377421694d49b56adf2d543
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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