Ammonium → [6-(2-chloro-benzylamino)-2-fluoro-pyridin-3-yl]-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

HRID 2329169Notes

Reaction equation

HRID 2329169 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([NH:9][CH2:10][c:11]2[c:12]([Cl:17])[cH:13][cH:14][cH:15][cH:16]2)[n:6][c:7]1[F:8].[C:23]([Li:24])([CH3:25])([CH3:26])[CH3:27].[CH2:18]([Li:19])[CH2:20][CH2:21][CH3:22].[CH:28]([CH3:29])([CH3:30])[Si:31]([n:32]1[cH:33][c:34]([CH:41]=[O:42])[c:35]2[c:36]1[n:37][cH:38][cH:39][cH:40]2)([CH:43]([CH3:44])[CH3:45])[CH:46]([CH3:47])[CH3:48].[Cl-:49].[NH4+:50].[O:51]1[CH2:52][CH2:53][CH2:54][CH2:55]1>>[c:2]1([CH:41]([c:34]2[cH:33][n:32]([Si:31]([CH:28]([CH3:29])[CH3:30])([CH:43]([CH3:44])[CH3:45])[CH:46]([CH3:47])[CH3:48])[c:36]3[c:35]2[cH:40][cH:39][cH:38][n:37]3)[OH:42])[cH:3][cH:4][c:5]([NH:9][CH2:10][c:11]2[c:12]([Cl:17])[cH:13][cH:14][cH:15][cH:16]2)[n:6][c:7]1[F:8]

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 8028TetrahydrofuranHCID 497589651H-Pyrrolo[2,3-B]pyridine-3-carboxaldehyde, 1-[tris(1-methylethyl)silyl]-HCID 57619357(5-Bromo-6-fluoro-pyridin-2-yl)-(2-chloro-benzyl)-amineHCID 178418306HCID 178418306, compoundHCID 178418339Butyllithium

Product 1

HCID 68804150[6-(2-chloro-benzylamino)-2-fluoro-pyridin-3-yl]-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

Sources & evidence

ORD record
ord-54e054cc41af422896040e2f31709526
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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