Tetrahydrofuran → 5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-3-prop-2-enyl-1-(1,1,1-trifluoro-2-hydroxy-2-methylpentan-3-yl)piperidin-2-one

HRID 2329184Notes

Reaction equation

HRID 2329184 reaction equation
[CH2:1]([CH:2]=[CH2:3])[C:4]1([CH3:31])[C:5](=[O:30])[N:6]([CH:24]([C:25]([CH3:26])=[O:27])[CH2:28][CH3:29])[CH:7]([c:17]2[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]2)[CH:8]([c:10]2[cH:11][c:12]([Cl:16])[cH:13][cH:14][cH:15]2)[CH2:9]1.[CH2:58]1[O:59][CH2:60][CH2:61][CH2:62]1.[CH3:32][Si:33]([C:34]([F:35])([F:36])[F:37])([CH3:38])[CH3:39].[CH3:41][CH2:42][CH2:43][CH2:44][N+:45]([CH2:46][CH2:47][CH2:48][CH3:49])([CH2:50][CH2:51][CH2:52][CH3:53])[CH2:54][CH2:55][CH2:56][CH3:57].[F-:40]>>[CH2:1]([CH:2]=[CH2:3])[C:4]1([CH3:31])[C:5](=[O:30])[N:6]([CH:24]([C:25]([CH3:26])([OH:27])[C:34]([F:35])([F:36])[F:37])[CH2:28][CH3:29])[CH:7]([c:17]2[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]2)[CH:8]([c:10]2[cH:11][c:12]([Cl:16])[cH:13][cH:14][cH:15]2)[CH2:9]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 552549(Trifluoromethyl)trimethylsilaneHCID 178438866HCID 178438866, compound

Product 1

HCID 1784388685-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-3-prop-2-enyl-1-(1,1,1-trifluoro-2-hydroxy-2-methylpentan-3-yl)piperidin-2-one

Sources & evidence

ORD record
ord-4ef52341f5884b0fbbd8d1eed0edbe0c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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