Tetrahydrofuran → methyl 4-(tert-butyl)-2-(1-Boc-piperidin-4-yloxy)benzoate

HRID 2329634Notes

Reaction equation

HRID 2329634 reaction equation
[C:16](=[O:17])([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[N:23]1[CH2:24][CH2:25][CH:26]([OH:29])[CH2:27][CH2:28]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([OH:15])[c:8]([C:9](=[O:10])[O:11][CH3:12])[cH:13][cH:14]1.[CH2:63]1[O:64][CH2:65][CH2:66][CH2:67]1.[O:49]=[C:50]([O:51][CH:52]([CH3:53])[CH3:54])[N:55]=[N:56][C:57]([O:58][CH:59]([CH3:60])[CH3:61])=[O:62].[c:30]1([P:31]([c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[cH:44][cH:45][cH:46][cH:47][cH:48]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([O:15][CH:26]2[CH2:25][CH2:24][N:23]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:28][CH2:27]2)[c:8]([C:9](=[O:10])[O:11][CH3:12])[cH:13][cH:14]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 20777194Methyl 4-tert-butyl-2-hydroxybenzoate

Product 1

HCID 68532357methyl 4-(tert-butyl)-2-(1-Boc-piperidin-4-yloxy)benzoate

Sources & evidence

ORD record
ord-3baa5a18989a49fcb325806ef8d0b643
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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