Tetrahydrofuran → 3-(3,4-Dichlorophenyl)-3-[3-(tetrahydropyran-4-yloxy)-propyl]-piperidine
Reaction equation
[Al+3:27].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[Cl:1][c:2]1[cH:3][c:4]([C:9]2([CH2:16][CH2:17][CH2:18][O:19][CH:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[CH2:10][CH2:11][C:12](=[O:15])[NH:13][CH2:14]2)[cH:5][cH:6][c:7]1[Cl:8].[H-:26].[H-:29].[H-:30].[H-:31].[Li+:28]>>[Cl:1][c:2]1[cH:3][c:4]([C:9]2([CH2:16][CH2:17][CH2:18][O:19][CH:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[CH2:10][CH2:11][CH2:12][NH:13][CH2:14]2)[cH:5][cH:6][c:7]1[Cl:8]Participants
6
Sources & evidence
- ORD record
- ord-f395e662a24945beb0953d97a0036626
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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