反应详情

To a solution of 3-(1-phenylmethyl-2-pyrrolidinyl)phenol (0.06 g) in dry tetrahydrofuran (30 ml) was added octyl isocyanate (0.44 ml) at ambient temperature, under nitrogen. The reaction mixture was stirred for 17 hrs and filtered through a pad of celite. The filter cake was washed with ethyl acetate and the combined filtrates were concentrated. The residue was purified by flash column chromatography (silica gel, dichloromethane). The appropriate fractions were collected and concentrated to give 0.50 g (52%) of product. The analytical sample was prepared by flushing the product through alumina with ether.

1. filtrationfiltered through a pad of celite
2. washThe filter cake was washed with ethyl acetate
3. concentrationthe combined filtrates were concentrated
4. customThe residue was purified by flash column chromatography (silica gel, dichloromethane)
5. customThe appropriate fractions were collected
6. concentrationconcentrated