Chloride → 1-(6-Bromo-pyridin-2-ylmethyl)-3-(3-fluoro-4-methoxy-benzoyl)-7-trifluoromethyl-1H-[1,8]naphthyridin-4-one

HRID 2332098Notes

Reaction equation

HRID 2332098 reaction equation
[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[CH3:1][O:2][N:3]([C:4](=[O:5])[c:6]1[cH:7][n:8]([CH2:21][c:22]2[n:23][c:24]([Br:28])[cH:25][cH:26][cH:27]2)[c:9]2[n:10][c:11]([C:17]([F:18])([F:19])[F:20])[cH:12][cH:13][c:14]2[c:15]1=[O:16])[CH3:29].[Cl-:30].[F:31][c:32]1[cH:33][c:34]([Mg+:40])[cH:35][cH:36][c:37]1[O:38][CH3:39]>>[C:4](=[O:5])([c:6]1[cH:7][n:8]([CH2:21][c:22]2[n:23][c:24]([Br:28])[cH:25][cH:26][cH:27]2)[c:9]2[n:10][c:11]([C:17]([F:18])([F:19])[F:20])[cH:12][cH:13][c:14]2[c:15]1=[O:16])[c:34]1[cH:33][c:32]([F:31])[c:37]([O:38][CH3:39])[cH:36][cH:35]1

Participants

5

Reactant 4

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 577547001-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-7-trifluoromethyl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid methoxy-methyl-amideHCID 178491922HCID 178491922, compound

Product 1

HCID 577545101-(6-Bromo-pyridin-2-ylmethyl)-3-(3-fluoro-4-methoxy-benzoyl)-7-trifluoromethyl-1H-[1,8]naphthyridin-4-one

Sources & evidence

ORD record
ord-993f06f0c58a4277aad27d86ce44bbd4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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