Tetrahydrofuran → 1-[6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazol-5-yl]-2-ethoxy-ethanone

HRID 2332582Notes

Reaction equation

HRID 2332582 reaction equation
[Br:21][c:22]1[cH:23][c:24]([Cl:41])[c:25]([NH:28][c:29]2[c:30]([CH:39]=[O:40])[cH:31][c:32]3[c:33]([n:34][cH:35][nH:36]3)[c:37]2[F:38])[cH:26][cH:27]1.[C:1]([c:2]1[cH:3][cH:4][c:5](-[c:6]2[cH:7][cH:8][c:9]([C:10]([CH3:11])([CH3:12])[CH3:13])[cH:14][cH:15]2)[cH:16][cH:17]1)([CH3:18])([CH3:19])[CH3:20].[CH2:42]1[CH2:43][CH2:44][CH2:45][O:46]1>>[Br:21][c:22]1[cH:23][c:24]([Cl:41])[c:25]([NH:28][c:29]2[c:30]([C:39](=[O:40])[CH2:42][O:46][CH2:45][CH3:44])[cH:31][c:32]3[c:33]([n:34][cH:35][nH:36]3)[c:37]2[F:38])[cH:26][cH:27]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylHCID 112456086-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carbaldehyde

Product 1

HCID 211141651-[6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazol-5-yl]-2-ethoxy-ethanone

Sources & evidence

ORD record
ord-94a5977abe454fb9b280e6937ad14620
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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