4-Hydroxybenzaldehyde → 4-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde

HRID 233312Notes

Reaction equation

Cl[CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[O:6][C:7]=1[CH3:8].[OH:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=[O:25])=[CH:22][CH:21]=1>>[CH3:8][C:7]1[O:6][C:5]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)=[N:4][C:3]=1[CH2:2][O:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=[O:25])=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 1264-Hydroxybenzaldehyde

HCID 121580734-(Chloromethyl)-5-methyl-2-(naphthalen-2-yl)-1,3-oxazole

Product 1

HCID 185461594-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde

Procedure

According to the method described for Reference Example 45, 4-chloromethyl-5-methyl-2-(2-naphthyl)oxazole was allowed to react with p-hydroxybenzaldehyde to give 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde. Recrystallization from chloroform-ether gave colorless prisms, m.p.163°-164° C.

Sources & evidence

ORD record: ord-c9e016b07ed549308a2ff9198fdbd080
Source dataset: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05591862

Reaction notes

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