Hydrochloric Acid → HCID 23356470, compound

HRID 233453Notes

Reaction equation

HRID 233453 reaction equation
[C:1]([C:3]1[N:7]2[CH:8]=[CH:9][N:10]=[C:11]([CH3:12])[C:6]2=[CH:5][CH:4]=1)#[N:2].Cl.[OH2:14]>>[C:1]([C:3]1[N:7]2[CH:8]=[CH:9][N:10]=[C:11]([CH3:12])[C:6]2=[CH:5][CH:4]=1)(=[O:14])[NH2:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 23356434HCID 23356434, compound

Product 1

HCID 23356470HCID 23356470, compound

Procedure

To 2.0 g of 6-cyano-1-methylpyrrolo[1,2-a]pyrazine prepared in Preparation Example 4 were added 10 ml of water and 5 ml of hydrochloric acid; and the reaction mixture was reacted at 80° C. for 2 hours, cooled to room temperature, extracted with ethyl acetate, and concentrated. The residue was chromatographed over silica gel to obtain 1.0 g of title compound.

Workup

  1. customand the reaction mixture was reacted at 80° C. for 2 hours
  2. extractionextracted with ethyl acetate
  3. concentrationconcentrated
  4. customThe residue was chromatographed over silica gel

Sources & evidence

ORD record
ord-4b28ef071c2f4c99be7f5b44da0e7b60
Source dataset
uspto-grants-1997_01
Patent number
US05593984

Reaction notes

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