Hydroxide → 4-[3,5-Dichloro-4-[[1-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]-2-oxopyrrolidin-3-yl]methyl]phenyl]benzoic acid

HRID 2334641Notes

Reaction equation

HRID 2334641 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:15](=[O:38])[CH:16]([CH2:19][c:20]3[c:21]([Cl:37])[cH:22][c:23](-[c:27]4[cH:28][cH:29][c:30]([C:33](=[O:34])[O:35][CH3:36])[cH:31][cH:32]4)[cH:24][c:25]3[Cl:26])[CH2:17][CH2:18]2)[CH2:12][CH2:13]1.[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[Li+:40].[OH-:39]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:15](=[O:38])[CH:16]([CH2:19][c:20]3[c:21]([Cl:37])[cH:22][c:23](-[c:27]4[cH:28][cH:29][c:30]([C:33](=[O:34])[OH:35])[cH:31][cH:32]4)[cH:24][c:25]3[Cl:26])[CH2:17][CH2:18]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 961HydroxideHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 66671552Tert-butyl 4-[3-[[2,6-dichloro-4-(4-methoxycarbonylphenyl)phenyl]methyl]-2-oxopyrrolidin-1-yl]piperidine-1-carboxylate

Product 1

HCID 666716494-[3,5-Dichloro-4-[[1-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]-2-oxopyrrolidin-3-yl]methyl]phenyl]benzoic acid

Sources & evidence

ORD record
ord-883b0cafadae41d4b188fb3f97032ed1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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