Methanesulfonic Acid → HCID 86750174, compound

HRID 233513Notes

Reaction equation

HRID 233513 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[OH:6][C@@H:7]1[C@@H:26]([N:27]2[CH2:32][CH2:31][O:30][C:29]([CH2:37][CH2:38][CH2:39][CH3:40])([CH2:33][CH2:34][CH2:35][CH3:36])[CH2:28]2)[CH2:25][C@@:24]2([CH3:41])[C@@H:9]([CH2:10][CH2:11][C@@H:12]3[C@@H:23]2[C:22](=[O:42])[CH2:21][C@@:20]2([CH3:43])[C@H:13]3[CH2:14][CH2:15][C@@H:16]2[C:17](=[O:19])[CH3:18])[CH2:8]1>C(O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[OH:6][C@@H:7]1[C@@H:26]([N:27]2[CH2:32][CH2:31][O:30][C:29]([CH2:37][CH2:38][CH2:39][CH3:40])([CH2:33][CH2:34][CH2:35][CH3:36])[CH2:28]2)[CH2:25][C@@:24]2([CH3:41])[C@@H:9]([CH2:10][CH2:11][C@@H:12]3[C@@H:23]2[C:22](=[O:42])[CH2:21][C@@:20]2([CH3:43])[C@H:13]3[CH2:14][CH2:15][C@@H:16]2[C:17](=[O:19])[CH3:18])[CH2:8]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 10626038HCID 10626038, compound

Product 1

HCID 86750174HCID 86750174, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of methanesulfonic acid (181 mg) in ethanol (7 ml) was added to a suspension of (2β,3α,5α)-3-hydroxy-2-(2,2-dibutyl-4-morpholinyl)pregnane-11,20-dione (1.0 g) in ethanol (3 ml). The resulting suspension was heated to effect solution and the solvent was removed under reduced pressure to give (2β,3α,5α)-3-hydroxy-2-(2,2-dibutyl-4-morpholinyl)pregnane-11,20-dione methanesulfonate (1:1) salt (1.06 g). [α]D +86.3° (c 0.7).

Workup

  1. temperatureThe resulting suspension was heated
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-3a6e17024d0d4c56976761e4221b3de2
Source dataset
uspto-grants-1997_01
Patent number
US05593983

Reaction notes

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