Tetrahydrofuran → 6-Cyano-1-fluoro-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene

HRID 2335246Notes

Reaction equation

HRID 2335246 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][c:5]2[c:10]([cH:11][cH:12]1)[CH:9]([c:13]1[cH:14][cH:15][n:16][s:17]1)[CH2:8][CH2:7][CH2:6]2.[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH:18]([N-:19][CH:20]([CH3:21])[CH3:22])([CH3:23])[CH3:24].[F:26][N:27]1[C:28]([CH3:29])([CH3:30])[c:31]2[cH:32][cH:33][cH:34][cH:35][c:36]2[S:37]1(=[O:38])=[O:39].[Li+:25]>>[C:1](#[N:2])[c:3]1[cH:4][c:5]2[c:10]([cH:11][cH:12]1)[C:9]([c:13]1[cH:14][cH:15][n:16][s:17]1)([F:26])[CH2:8][CH2:7][CH2:6]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 5062348DiisopropylamideHCID 51409122-Fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxideHCID 189490196-Cyano-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene

Product 1

HCID 189490226-Cyano-1-fluoro-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene

Sources & evidence

ORD record
ord-a5b3e4b31a6f49a7b6aa1c80f474b240
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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