Dimethylformamide → Tert-butyl-2,2-difluoro-4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

HRID 2336100Notes

Reaction equation

HRID 2336100 reaction equation
[CH3:56][CH2:57][N:58]([CH2:59][CH3:60])[CH2:61][CH3:62].[CH:45]([CH3:46])([CH3:47])[c:48]1[s:49][cH:50][c:51]([C:53](=[O:54])[OH:55])[n:52]1.[F:25][C:26]1([F:44])[O:27][C:28]2([CH2:29][NH:30][CH2:31]1)[CH2:32][CH2:33][N:34]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:35][CH2:36]2.[O:63]=[CH:64][N:65]([CH3:66])[CH3:67].[P-:1]([F:2])([F:3])([F:4])([F:5])([F:6])[F:7].[n:8]1([O:9][C:10]([N:11]([CH3:12])[CH3:13])=[N+:14]([CH3:15])[CH3:16])[c:17]2[n:18][cH:19][cH:20][cH:21][c:22]2[n:23][n:24]1>>[F:25][C:26]1([F:44])[O:27][C:28]2([CH2:29][N:30]([C:53]([c:51]3[cH:50][s:49][c:48]([CH:45]([CH3:46])[CH3:47])[n:52]3)=[O:54])[CH2:31]1)[CH2:32][CH2:33][N:34]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:35][CH2:36]2

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 225730652-(Propan-2-yl)-1,3-thiazole-4-carboxylic acidHCID 57989014tert-Butyl 2,2-difluoro-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Product 1

HCID 57989035Tert-butyl-2,2-difluoro-4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Sources & evidence

ORD record
ord-9cadae065169472da463f7e588a03271
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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