Dimethylformamide → tert-butyl N-[7a-[5-[(5-cyanopyridine-2-carbonyl)amino]-2-fluorophenyl]-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-yl]carbamate

HRID 2337167Notes

Reaction equation

HRID 2337167 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([C:9](=[O:10])[OH:11])[n:7][cH:8]1.[CH:61]([N:62]([CH2:63][CH3:64])[CH:65]([CH3:66])[CH3:67])([CH3:68])[CH3:69].[NH2:12][c:13]1[cH:14][cH:15][c:16]([F:36])[c:17]([C:19]23[N:20]=[C:21]([NH:28][C:29]([O:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:35])[S:22][CH2:23][CH:24]2[CH2:25][CH2:26][O:27]3)[cH:18]1.[O:70]=[CH:71][N:72]([CH3:73])[CH3:74].[P-:37]([F:38])([F:39])([F:40])([F:41])([F:42])[F:43].[n:44]1([O:45][C:46]([N:47]([CH3:48])[CH3:49])=[N+:50]([CH3:51])[CH3:52])[c:53]2[n:54][cH:55][cH:56][cH:57][c:58]2[n:59][n:60]1>>[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([C:9](=[O:11])[NH:12][c:13]2[cH:14][cH:15][c:16]([F:36])[c:17]([C:19]34[N:20]=[C:21]([NH:28][C:29]([O:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:35])[S:22][CH2:23][CH:24]3[CH2:25][CH2:26][O:27]4)[cH:18]2)[n:7][cH:8]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 124007345-Cyanopyridine-2-carboxylic acidHCID 123188868tert-butyl N-[7a-(5-amino-2-fluorophenyl)-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-yl]carbamate

Product 1

HCID 123399491tert-butyl N-[7a-[5-[(5-cyanopyridine-2-carbonyl)amino]-2-fluorophenyl]-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-yl]carbamate

Sources & evidence

ORD record
ord-cd2e454b271a40b5857196817e7fb329
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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