Dimethylformamide → (R)-tert-Butyl (1-(4-chlorobenzyl)pyrrolidin-3-yl)carbamate

HRID 2337488Notes

Reaction equation

HRID 2337488 reaction equation
[C:19]([CH3:20])([CH3:21])([CH3:22])[O:23][C:24](=[O:25])[NH:26][CH:27]1[CH2:28][NH:29][CH2:30][CH2:31]1.[CH:10]([N:11]([CH2:12][CH3:13])[CH:14]([CH3:15])[CH3:16])([CH3:17])[CH3:18].[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][Cl:7])[cH:8][cH:9]1.[O:32]=[CH:33][N:34]([CH3:35])[CH3:36]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:29]2[CH2:28][CH:27]([NH:26][C:24]([O:23][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:25])[CH2:31][CH2:30]2)[cH:8][cH:9]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 77231-Chloro-4-(chloromethyl)benzeneHCID 81531DiisopropylethylamineHCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamate

Product 1

HCID 18426224(R)-tert-Butyl (1-(4-chlorobenzyl)pyrrolidin-3-yl)carbamate

Sources & evidence

ORD record
ord-297533513d914fda9b1a3a96bade0cd1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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