Dimethylformamide → 2-(4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)naphthalene-1-yl)piperidin-1-yl)acetamide

HRID 2337866Notes

Reaction equation

HRID 2337866 reaction equation
[Br:32][CH2:33][C:34](=[O:35])[NH2:36].[CH3:37][CH2:38][N:39]([CH2:40][CH3:41])[CH2:42][CH3:43].[Cl:1][c:2]1[c:3]([NH:25][c:26]2[n:27][nH:28][c:29]([CH3:31])[cH:30]2)[n:4][c:5]([NH:8][c:9]2[cH:10][cH:11][c:12]([CH:19]3[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]3)[c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]23)[n:6][cH:7]1.[O:44]=[CH:45][N:46]([CH3:47])[CH3:48]>>[Cl:1][c:2]1[c:3]([NH:25][c:26]2[n:27][nH:28][c:29]([CH3:31])[cH:30]2)[n:4][c:5]([NH:8][c:9]2[cH:10][cH:11][c:12]([CH:19]3[CH2:20][CH2:21][N:22]([CH2:33][C:34](=[O:35])[NH2:36])[CH2:23][CH2:24]3)[c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]23)[n:6][cH:7]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 696322-BromoacetamideHCID 582571215-chloro-N4-(5-methyl-1H-pyrazol-3-yl)-N2-(4-(piperidin-4-yl)naphthalene-1-yl)pyrimidine-2,4-diamine

Product 1

HCID 582571192-(4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)naphthalene-1-yl)piperidin-1-yl)acetamide

Sources & evidence

ORD record
ord-7ace432f4eb844848e936937619202f7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…