Dimethylformamide → HCID 11122592, compound

HRID 233822Notes

Reaction equation

HRID 233822 reaction equation
[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[C:14](=[CH:15][C:16]([O:20][CH3:21])=[C:17]([OH:19])[CH:18]=3)[C:9]3[C:10]2=[C:5]([CH:6]=[C:7]([OH:24])[C:8]=3[O:22][CH3:23])[CH2:4][CH2:3]1.C(Cl)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[CH3:33]N(C=O)C>>[CH3:33][N:2]([CH2:1][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH2:11][CH2:12][C:13]1[C:14]2[CH:9]=[CH:10][C:5]3[C:4]([C:15]=2[C:16]([O:20][CH3:21])=[C:17]([OH:19])[CH:18]=1)=[CH:3][C:8]([O:22][CH3:23])=[C:7]([OH:24])[CH:6]=3

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 7503Benzyl ChlorideHCID 10154(+)-Boldine

Product 1

HCID 11122592HCID 11122592, compound

Procedure

1 g of boldine was dissolved in 30 ml of (DMF), the mixture was reacted with 1.2 ml of benzyl chloride at 100°-110° C. for 2 hrs. The residue obtained after evaporation under reduced pressure was purified to give the pure compound (5) N-benzylsecoboldine.

Workup

  1. customThe residue obtained
  2. customafter evaporation under reduced pressure
  3. customwas purified

Sources & evidence

ORD record
ord-a5735dddb0d24067a369730333bf50a7
Source dataset
uspto-grants-1997_01
Patent number
US05594033

Reaction notes

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