Dichloromethane → 3,3-Bis(4-fluorophenyl)-1-(2-(piperazin-1-yl)ethyl)pyrrolidin-2-one

HRID 2338780Notes

Reaction equation

HRID 2338780 reaction equation
[CH3:43][CH2:44][N:45]([CH2:46][CH3:47])[CH2:48][CH3:49].[Cl:50][CH2:51][Cl:52].[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([c:29]3[cH:30][cH:31][c:32]([F:35])[cH:33][cH:34]3)[C:9](=[O:28])[N:10]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][N:18]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:19][CH2:20]3)[CH2:11][CH2:12]2)[cH:6][cH:7]1.[OH:36][C:37]([C:38]([F:39])([F:40])[F:41])=[O:42]>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([c:29]3[cH:30][cH:31][c:32]([F:35])[cH:33][cH:34]3)[C:9](=[O:28])[N:10]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[CH2:11][CH2:12]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 67359885Tert-butyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)ethyl)piperazine-1-carboxylate

Product 1

HCID 674430113,3-Bis(4-fluorophenyl)-1-(2-(piperazin-1-yl)ethyl)pyrrolidin-2-one

Sources & evidence

ORD record
ord-b350b1860efb4c60a596cd3587cdb799
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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