Imidazole → 3-Bromo-5-((triisopropylsilyloxy)methyl)pyridine

HRID 2339061Notes

Reaction equation

[Br:1][c:2]1[cH:3][c:4]([CH2:8][OH:9])[cH:5][n:6][cH:7]1.[CH:15]([CH3:16])([CH3:17])[Si:18]([CH:19]([CH3:20])[CH3:21])([CH:22]([CH3:23])[CH3:24])[Cl:25].[O:26]=[CH:27][N:28]([CH3:29])[CH3:30].[nH:10]1[cH:11][cH:12][n:13][cH:14]1>>[Br:1][c:2]1[cH:3][c:4]([CH2:8][O:9][Si:18]([CH:15]([CH3:16])[CH3:17])([CH:19]([CH3:20])[CH3:21])[CH:22]([CH3:23])[CH3:24])[cH:5][n:6][cH:7]1

Participants

Reactant 4

HCID 795Imidazole

HCID 6228Dimethylformamide

HCID 139400Triisopropylsilyl chloride

HCID 2784733(5-Bromo-3-pyridinyl)methanol

Product 1

HCID 121095753-Bromo-5-((triisopropylsilyloxy)methyl)pyridine

Sources & evidence

ORD record: ord-5aa3cfd0a00d4bf8af36204456f930f4
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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