Pyridine → 7-Chloro-4-(4-methoxyphenyl)-3-methyl-1,3,4,5-tetrahydro-1-benzazepin-2-one

HRID 2339756Notes

Reaction equation

HRID 2339756 reaction equation
[CH3:35][CH2:36][O:37][C:38](=[O:39])[CH3:40].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:26]1)[CH2:7][CH:8]([c:18]1[cH:19][cH:20][c:21]([O:24][CH3:25])[cH:22][cH:23]1)[C:9]([CH3:13])([C:14]([O:15][CH3:16])=[O:17])[C:10](=[O:12])[NH:11]2.[I-:27].[Li+:28].[cH:29]1[cH:30][cH:31][n:32][cH:33][cH:34]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:26]1)[CH2:7][CH:8]([c:18]1[cH:19][cH:20][c:21]([O:24][CH3:25])[cH:22][cH:23]1)[CH:9]([CH3:13])[C:10](=[O:12])[NH:11]2

Participants

6

Reactant 5

HCID 1049PyridineHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 30165Iodide IonHCID 15128679HCID 15128679, compound

Product 1

HCID 156121027-Chloro-4-(4-methoxyphenyl)-3-methyl-1,3,4,5-tetrahydro-1-benzazepin-2-one

Sources & evidence

ORD record
ord-d5bf95b5a5764fb8b651b7ec46ff2c2a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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