Hydrochloric Acid → 4-(4-Chloro-2-fluoroanilino)-6-methoxy-7-(2-(2-pyridyloxy)ethoxy)quinazoline
Reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([OH:19])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1.[Cl:24][CH2:25][CH2:26][O:27][c:28]1[n:29][cH:30][cH:31][cH:32][cH:33]1.[ClH:23].[K+:38].[K+:39].[O:40]=[CH:41][N:42]([CH3:43])[CH3:44].[OH2:45]>>[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([O:19][CH2:25][CH2:26][O:27][c:28]4[n:29][cH:30][cH:31][cH:32][cH:33]4)[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-97724887caef4fbf92000793c6499f82
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
Loading…