反应详情

To a solution of 4-bromo-1-indanone (1.0 g) in a mixture of ethanol (6 ml) and tetrahydrofuran (3 ml) was added sodium borohydride (0.09 g) at an ice temperature. The reaction mixture was stirred at the same temperature overnight and poured into dilute hydrochloric acid, and the aqueous layer was saturated with saline and extracted with ether. The organic layer was washed with a saturated aqueous saline, dried over sodium sulfate, and the solvent was removed by distillation under reduced pressure. The residual concentrate (1.02 g) thus obtained was used for the next reaction without further purification.

1. extractionextracted with ether
2. washThe organic layer was washed with a saturated aqueous saline
3. dry with materialdried over sodium sulfate
4. customthe solvent was removed by distillation under reduced pressure
5. concentrationThe residual concentrate (1.02 g)
6. customthus obtained
7. customwas used for the next reaction without further purification