Hydrochloric Acid → HCID 23358292, compound

HRID 234080Notes

Reaction equation

HRID 234080 reaction equation
[C:1]([CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[Br:14])[C:6]1=[O:15])([CH3:4])([CH3:3])[CH3:2].[BH4-].[Na+].Cl>CO.O1CCCC1>[C:1]([CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[Br:14])[CH:6]1[OH:15])([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 23358299HCID 23358299, compound

Product 1

HCID 23358292HCID 23358292, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-tert-butyl-4-bromo-1-indanone in a mixture of methanol (100 ml) and tetrahydrofuran (200 ml) was added sodium borohydride (1.58 g) at room temperature. After stirring at the same temperature, the reaction mixture was poured into dilute hydrochloric acid, and the aqueous layer was saturated with saline and extracted with ether. The organic layer was saturated with a saturated aqueous saline solution, dried over magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The residual concentrate (7.49 g) thus obtained was used for the next reaction without further purification.

Workup

  1. extractionextracted with ether
  2. dry with materialdried over magnesium sulfate
  3. customthe solvent was removed by distillation under reduced pressure
  4. concentrationThe residual concentrate (7.49 g)
  5. customthus obtained
  6. customwas used for the next reaction without further purification

Sources & evidence

ORD record
ord-b34fd40512854abeaa18260ae5d9b250
Source dataset
uspto-grants-1997_01
Patent number
US05594081

Reaction notes

Loading…