Trifluoroacetic acid → Trifluoroacetate

HRID 234141Notes

Reaction equation

HRID 234141 reaction equation
F[C:2](F)(F)[C:3](O)=O.S1C2CCNCC=2C=C1C([NH:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]([OH:32])=[O:31])=[C:24](OCC(O)=O)[CH:23]=1)=O.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>C1(OC)C=CC=CC=1>[NH2:19][CH2:20][CH2:21][C:22]1[CH:23]=[CH:24][C:25]([O:28][CH2:29][C:30]([O:32][CH2:2][CH3:3])=[O:31])=[CH:26][CH:27]=1.[F:38][C:39]([F:44])([F:43])[C:40]([O-:42])=[O:41]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67623119HCID 67623119, compound

Product 2

HCID 84468TrifluoroacetateHCID 11118784HCID 11118784, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Procedure

To the solution of the compound prepared in (b) (2 g) in anisole (3.3 ml) was added trifluoroacetic acid (3 ml), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure. The residue was washed with n-hexane, dissolved in water and lyophilized to give the title compound in the form of a trifluoroacetate.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washThe residue was washed with n-hexane
  3. dissolutiondissolved in water

Sources & evidence

ORD record
ord-49deadf7b1af4124a45c07892d5ef131
Source dataset
uspto-grants-1997_01
Patent number
US05594004

Reaction notes

Loading…