Tetrahydrofuran → 4-(4-Hydroxymethyl-thiazol-2-yl)-4-methyl-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[Al+3:26].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH3:14])([c:15]2[s:16][cH:17][c:18]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[n:19]2)[CH2:12][CH2:13]1.[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[H-:25].[H-:28].[H-:29].[H-:30].[Li+:27]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH3:14])([c:15]2[s:16][cH:17][c:18]([CH2:20][OH:21])[n:19]2)[CH2:12][CH2:13]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-25ad92ab15be47078b0ab1954d4cbc6b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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