Dimethylformamide → 4-[[2-[4-[(2-Chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methyl-pyrazol-1-yl]-3-pyridyl]methyl]morpholin-3-one

HRID 2341944Notes

Reaction equation

HRID 2341944 reaction equation
[Br:25][c:26]1[n:27][cH:28][cH:29][cH:30][c:31]1[CH2:32][N:33]1[C:34](=[O:39])[CH2:35][O:36][CH2:37][CH2:38]1.[C:40](=[O:41])([O-:42])[O-:43].[CH3:46][NH:47][CH:48]1[CH2:49][CH2:50][CH2:51][CH2:52][CH:53]1[NH:54][CH3:55].[CH3:56][N:57]([CH3:58])[CH:59]=[O:60].[Cl:1][c:2]1[cH:3][c:4]2[c:5]([s:24]1)[C:6]1([O:7][CH2:8][C:9]2([F:10])[F:11])[CH2:12][CH2:13][N:14]([CH2:17][c:18]2[c:19]([CH3:23])[n:20][nH:21][cH:22]2)[CH2:15][CH2:16]1.[Cs+:44].[Cs+:45].[Cu:61][I:62]>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([s:24]1)[C:6]1([O:7][CH2:8][C:9]2([F:10])[F:11])[CH2:12][CH2:13][N:14]([CH2:17][c:18]2[c:19]([CH3:23])[n:20][n:21](-[c:26]3[n:27][cH:28][cH:29][cH:30][c:31]3[CH2:32][N:33]3[C:34](=[O:39])[CH2:35][O:36][CH2:37][CH2:38]3)[cH:22]2)[CH2:15][CH2:16]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 5510741-N,2-N-dimethylcyclohexane-1,2-diamineHCID 582686224-((2-Bromopyridin-3-yl)methyl)morpholin-3-oneHCID 178434546HCID 178434546, compound

Product 1

HCID 582686364-[[2-[4-[(2-Chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methyl-pyrazol-1-yl]-3-pyridyl]methyl]morpholin-3-one

Sources & evidence

ORD record
ord-695454fa20104592a74637b45205f033
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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