Dichloromethane → tert-butyl N-(1-cyano-1-methylethyl)carbamate

HRID 2342151Notes

Reaction equation

HRID 2342151 reaction equation
[CH2:35]([Cl:36])[Cl:37].[CH3:15][CH2:16][N:17]([CH2:18][CH3:19])[CH2:20][CH3:21].[F:22][C:23]([F:24])([F:25])[C:26]([O:27][C:28](=[O:29])[C:30]([F:31])([F:32])[F:33])=[O:34].[NH2:1][C:2]([C:3]([CH3:4])([CH3:5])[NH:6][C:7]([O:8][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:13])=[O:14]>>[N:1]#[C:2][C:3]([CH3:4])([CH3:5])[NH:6][C:7]([O:8][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:13]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 9845Trifluoroacetic anhydrideHCID 11287144tert-Butyl (1-amino-2-methyl-1-oxopropan-2-yl)carbamate

Product 1

HCID 18316698tert-butyl N-(1-cyano-1-methylethyl)carbamate

Sources & evidence

ORD record
ord-2d6aa992cd5843ad830ef1c2787376e9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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