反应详情

温度

80 °C

Potassium carbonate (74.0 g, 0.54 mol) was added to a solution of 4-formylamino-2,3,5-trimethylphenol (85.5 g, 0.48 mol) and methallyl chloride (45.3 g, 0.5 mol) in dimethylformamide (300 ml) and the mixture was stirred at 80° C. for 3 hours under an argon atmosphere. The reaction mixture was poured into ice-cold water. Crystals precipitated were filtered, washed with water and dried. The crude crystals obtained were recrystallized from isopropyl ether to obtain the desired compound (80.0 g, yield: 71.6%), m.p. 144°-145° C.

1. additionThe reaction mixture was poured into ice-cold water
2. customCrystals precipitated
3. filtrationwere filtered
4. washwashed with water
5. customdried
6. customThe crude crystals obtained
7. customwere recrystallized from isopropyl ether