Dimethylformamide → 2-Ethyl-5-methylbenzo[b]thiophene-3-sulfonylchloride

HRID 234389Notizen

Reaktionsgleichung

CN(C=O)C.[S:6]([Cl:10])(Cl)(=[O:8])=[O:7].[CH2:11]([C:13]1[S:17][C:16]2[CH:18]=[CH:19][C:20]([CH3:22])=[CH:21][C:15]=2[CH:14]=1)[CH3:12]>>[CH2:11]([C:13]1[S:17][C:16]2[CH:18]=[CH:19][C:20]([CH3:22])=[CH:21][C:15]=2[C:14]=1[S:6]([Cl:10])(=[O:8])=[O:7])[CH3:12]

Komponenten

Edukt 3

HCID 6228Dimethylformamide

HCID 24648Sulfuryl chloride

HCID 5953442-Ethyl-5-methylbenzo[b]thiophene

Produkt 1

HCID 229984372-Ethyl-5-methylbenzo[b]thiophene-3-sulfonylchloride

Versuchsvorschrift

2-ethyl-5-methylbenzo[b]thiophene-3-sulfonylchloride was prepared in the same manner as described in Example 40B. Reaction of DMF (6.5 mmoles, 0.50 ml), sulfurylchloride (5.5 mmoles, 0.44 ml) and 2-ethyl-5-methylbenzo[b]thiophene (3.2 mmoles, 0.57 g) yielded, after flash chromatography, using 2% ethyl acetate/hexanes, 0.58 g (66%) of an orange solid.

Aufarbeitung

customyielded

Quellen und Nachweise

ORD-Eintrag: ord-2e1a80b3724f4af0a24c693dc6673ddd
Quelldatensatz: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05594021

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