Water → tert-Butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-9-ylmethoxy)piperidine-1-carboxylate

HRID 2345080Notes

Reaction equation

HRID 2345080 reaction equation
[CH3:1][O:2][c:3]1[c:4]([CH2:5][O:6][CH2:7][CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][c:14]([CH:17]3[CH:18]([O:30][CH2:31][c:32]4[cH:33][cH:34][cH:35][c:36]5[c:37]4[N:38]([CH2:44][O:45][CH2:46][CH2:47][Si:48]([CH3:49])([CH3:50])[CH3:51])[C:39](=[O:43])[CH2:40][CH2:41][CH2:42]5)[CH2:19][N:20]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:21][CH2:22]3)[cH:15][cH:16]2)[cH:52][cH:53][cH:54][cH:55]1.[CH3:57][CH2:58][CH2:59][CH2:60][N+:61]([CH2:62][CH2:63][CH2:64][CH3:65])([CH2:66][CH2:67][CH2:68][CH3:69])[CH2:70][CH2:71][CH2:72][CH3:73].[CH3:75][O:76][C:77]([CH3:78])([CH3:79])[CH3:80].[F-:56].[O:81]1[CH2:82][CH2:83][CH2:84][CH2:85]1.[OH2:74]>>[CH3:1][O:2][c:3]1[c:4]([CH2:5][O:6][CH2:7][CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][c:14]([CH:17]3[CH:18]([O:30][CH2:31][c:32]4[cH:33][cH:34][cH:35][c:36]5[c:37]4[NH:38][C:39](=[O:43])[CH2:40][CH2:41][CH2:42]5)[CH2:19][N:20]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:21][CH2:22]3)[cH:15][cH:16]2)[cH:52][cH:53][cH:54][cH:55]1

Participants

7

Reactant 6

HCID 962WaterHCID 8028TetrahydrofuranHCID 15413tert-Butyl methyl etherHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 68503548tert-butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-(2-oxo-1-(2-trimethylsilanylethoxymethyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-9-ylmethoxy)piperidine-1-carboxylate

Product 1

HCID 68635087tert-Butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-9-ylmethoxy)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-c3a10413eb5046f3a30f12275ca7841e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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