Water → Methyl 2-[[2-[4-(4-methoxy-3-methylphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanoyl]amino]-1,3-thiazole-4-carboxylate

HRID 2345527Notes

Reaction equation

HRID 2345527 reaction equation
[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7]([NH:10][C:11]([CH:12]([CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)[NH:20][C:21]([CH:22]([c:23]2[cH:24][c:25]([CH3:31])[c:26]([O:29][CH3:30])[cH:27][cH:28]2)[NH2:32])=[O:33])=[O:34])[s:8][cH:9]1.[CH:35]([N:36]([CH:37]([CH3:38])[CH3:39])[CH2:40][CH3:41])([CH3:42])[CH3:43].[Cl:53][CH2:54][Cl:55].[O:44]=[C:45]([Cl:46])[O:47][C:48]([Cl:49])([Cl:50])[Cl:51].[OH2:52]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7]([NH:10][C:11]([CH:12]([CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)[N:20]2[C:21](=[O:33])[CH:22]([c:23]3[cH:24][c:25]([CH3:31])[c:26]([O:29][CH3:30])[cH:27][cH:28]3)[NH:32][C:45]2=[O:44])=[O:34])[s:8][cH:9]1

Participants

6

Reactant 5

HCID 962WaterHCID 6344DichloromethaneHCID 10426DiphosgeneHCID 81531DiisopropylethylamineHCID 87580044Methyl 2-[[2-[[2-amino-2-(4-methoxy-3-methylphenyl)acetyl]amino]-3-phenylpropanoyl]amino]-1,3-thiazole-4-carboxylate

Product 1

HCID 76839225Methyl 2-[[2-[4-(4-methoxy-3-methylphenyl)-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanoyl]amino]-1,3-thiazole-4-carboxylate

Sources & evidence

ORD record
ord-3c37179a9a1a4b5fb91f154b4da29699
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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