Pyrrolidine → trans-N-methyl-N-[4-(4-pyrrolidin-1-yl-butoxymethyl)-cyclohexylmethyl]-4-trifluoromethyl-benzenesulfonamide

HRID 2345539Notes

Reaction equation

HRID 2345539 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][CH2:7][CH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]([S:16](=[O:17])(=[O:18])[c:19]2[cH:20][cH:21][c:22]([C:25]([F:26])([F:27])[F:28])[cH:23][cH:24]2)[CH3:29])[CH2:12][CH2:13]1.[CH2:30]1[CH2:31][CH2:32][NH:33][CH2:34]1.[CH3:35][N:36]([CH3:37])[C:38](=[O:39])[CH3:40]>>[CH2:2]([CH2:3][CH2:4][CH2:5][O:6][CH2:7][CH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]([S:16](=[O:17])(=[O:18])[c:19]2[cH:20][cH:21][c:22]([C:25]([F:26])([F:27])[F:28])[cH:23][cH:24]2)[CH3:29])[CH2:12][CH2:13]1)[N:33]1[CH2:32][CH2:31][CH2:30][CH2:34]1

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 31374DimethylacetamideHCID 22294178trans-N-[4-(4-bromo-butoxymethyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide

Product 1

HCID 22294151trans-N-methyl-N-[4-(4-pyrrolidin-1-yl-butoxymethyl)-cyclohexylmethyl]-4-trifluoromethyl-benzenesulfonamide

Sources & evidence

ORD record
ord-b24502f88cc34379aa588c0618cd0186
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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