Methanol → rac-(2'S,3'S,4'S)-6-chloro-2'-(3-chloro-2-fluoro-phenyl)-4'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-1'-carboxylic acid 4-carboxy-benzyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([CH2:9][O:10][C:11](=[O:12])[N:13]2[CH:14]([c:33]3[c:34]([F:40])[c:35]([Cl:39])[cH:36][cH:37][cH:38]3)[C:15]3([C:16](=[O:25])[NH:17][c:18]4[cH:19][c:20]([Cl:24])[cH:21][cH:22][c:23]43)[CH:26]([CH2:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:27]2)[cH:41][cH:42]1.[CH3:45][OH:46].[Li+:44].[O:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1.[OH-:43].[OH2:52]>>[O:2]=[C:3]([OH:4])[c:5]1[cH:6][cH:7][c:8]([CH2:9][O:10][C:11](=[O:12])[N:13]2[CH:14]([c:33]3[c:34]([F:40])[c:35]([Cl:39])[cH:36][cH:37][cH:38]3)[C:15]3([C:16](=[O:25])[NH:17][c:18]4[cH:19][c:20]([Cl:24])[cH:21][cH:22][c:23]43)[CH:26]([CH2:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:27]2)[cH:41][cH:42]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-670073cf9c154ffaa21f59a0b5499af9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
Loading…