Tetrahydrofuran → HCID 66600266, compound

HRID 2346257Notes

Reaction equation

HRID 2346257 reaction equation
[CH2:47]1[O:48][CH2:49][CH2:50][CH2:51]1.[CH3:37][Si:38]([NH:39][Si:40]([CH3:41])([CH3:42])[CH3:43])([CH3:44])[CH3:45].[F:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[c:9]2[n:10][cH:11][n:12]([CH:18]3[O:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[c:13]2[n:14][c:15]([CH3:17])[n:16]1.[Li:46].[NH2:24][c:25]1[cH:26][cH:27][c:28]([NH:31][C:32](=[O:33])[CH:34]2[CH2:35][CH2:36]2)[cH:29][cH:30]1>>[c:2]1([NH:24][c:25]2[cH:26][cH:27][c:28]([NH:31][C:32](=[O:33])[CH:34]3[CH2:35][CH2:36]3)[cH:29][cH:30]2)[n:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[c:9]2[n:10][cH:11][n:12]([CH:18]3[O:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[c:13]2[n:14][c:15]([CH3:17])[n:16]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 13838HexamethyldisilazaneHCID 3028194LithiumHCID 16227631N-(4-Aminophenyl)cyclopropanecarboxamideHCID 595484686-(2-fluoropyridin-3-yl)-2-methyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Product 1

HCID 66600266HCID 66600266, compound

Sources & evidence

ORD record
ord-ca117f4416444c419e247acfa59a13f0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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