Tetrahydrofuran → (RS)-(4-cyano-phenylamino)-(5-ethoxy-2-fluoro-3-hydroxy-phenyl)-acetic acid ethyl ester
Reaction equation
[CH2:1]([CH3:2])[O:3][C:4]([CH:5]([NH:6][c:7]1[cH:8][cH:9][c:10]([C:13]#[N:14])[cH:11][cH:12]1)[c:15]1[c:16]([F:42])[c:17]([O:24][Si:25]([C:26]([CH3:27])([CH3:28])[CH3:29])([c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[cH:18][c:19]([O:21][CH2:22][CH3:23])[cH:20]1)=[O:43].[CH2:68]1[O:69][CH2:70][CH2:71][CH2:72]1.[CH3:45][CH2:46][CH2:47][CH2:48][N+:49]([CH2:50][CH2:51][CH2:52][CH3:53])([CH2:54][CH2:55][CH2:56][CH3:57])[CH2:58][CH2:59][CH2:60][CH3:61].[CH3:62][CH2:63][O:64][C:65]([CH3:66])=[O:67].[F-:44]>>[CH2:1]([CH3:2])[O:3][C:4]([CH:5]([NH:6][c:7]1[cH:8][cH:9][c:10]([C:13]#[N:14])[cH:11][cH:12]1)[c:15]1[c:16]([F:42])[c:17]([OH:24])[cH:18][c:19]([O:21][CH2:22][CH3:23])[cH:20]1)=[O:43]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-35e47357796b4fe691e2b8684477f1bd
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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