Hydrochloric Acid → HCID 86750229, compound

HRID 234747Notes

Reaction equation

HRID 234747 reaction equation
C([NH:20][CH:21]1[CH:28]2[CH2:29][CH:24]3[CH2:25][CH:26]([CH2:30][C:22]1([O:31][CH2:32][C:33]1[CH:38]=[CH:37][C:36]([C:39]4[O:40][C:41]5[CH:47]=[CH:46][CH:45]=[CH:44][C:42]=5[N:43]=4)=[CH:35][CH:34]=1)[CH2:23]3)[CH2:27]2)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[ClH:48]>>[ClH:48].[O:40]1[C:41]2[CH:47]=[CH:46][CH:45]=[CH:44][C:42]=2[N:43]=[C:39]1[C:36]1[CH:35]=[CH:34][C:33]([CH2:32][O:31][C:22]23[CH2:30][CH:26]4[CH2:25][CH:24]([CH2:29][CH:28]([CH2:27]4)[CH:21]2[NH2:20])[CH2:23]3)=[CH:38][CH:37]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 54303745N-trityl-1-[4-(benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7]-decan-2-amine

Product 1

HCID 86750229HCID 86750229, compound

Procedure

N-trityl-1-[4-(benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7 ]-decan-2-amine (0.88 g; 0.0014 mole) is combined with ethanolic HCl (20 ml). After 2 hours, TLC indicates the reaction is complete. The reaction mixture is evaporated to dryness and purified on a flash column, using 10% MeOH/CH2Cl2 to obtain 1-[4-(benzoxazol-2-yl)benzyloxy]-tricyclo[3.3.1.13,7 ]-decan-2-amine hydrochloride (m.p. 291°-293° C.).

Workup

  1. customThe reaction mixture is evaporated to dryness
  2. custompurified on a flash column

Sources & evidence

ORD record
ord-932d53a90ec640948c5776398fcf5c68
Source dataset
uspto-grants-1997_01
Patent number
US05596020

Reaction notes

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