Diethyl Ether → 4-Ethyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one
Reaction equation
[CH3:57][CH2:58][O:59][CH2:60][CH3:61].[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([NH:9][C:10]([CH2:11][CH:12]([CH2:13][CH3:14])[OH:15])=[O:16])[cH:7][cH:8]1)([F:17])[F:18].[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1.[O:43]=[C:44]([O:45][CH:46]([CH3:47])[CH3:48])[N:49]=[N:50][C:51]([O:52][CH:53]([CH3:54])[CH3:55])=[O:56].[c:19]1([P:20]([c:21]2[cH:22][cH:23][cH:24][cH:25][cH:26]2)[c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[cH:33][cH:34][cH:35][cH:36][cH:37]1>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([N:9]2[C:10](=[O:16])[CH2:11][CH:12]2[CH2:13][CH3:14])[cH:7][cH:8]1)([F:17])[F:18]Participants
6
Sources & evidence
- ORD record
- ord-0e363b6a6ce944528d5adde997904465
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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