Hydrogen Bromide → 1-[4-(3-Trifluoromethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl]-2-(6-hydroxy-naphth-2-yl)ethane hydrobromide

HRID 234801Notes

Reaction equation

HRID 234801 reaction equation
Cl.[F:2][C:3]([F:31])([F:30])[C:4]1[CH:5]=[C:6]([C:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C:18]3[CH:27]=[CH:26][C:25]4[C:20](=[CH:21][CH:22]=[C:23]([O:28]C)[CH:24]=4)[CH:19]=3)[CH2:14][CH:15]=2)[CH:7]=[CH:8][CH:9]=1.[BrH:32]>C(O)(=O)C>[BrH:32].[F:30][C:3]([F:2])([F:31])[C:4]1[CH:5]=[C:6]([C:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:27]=[CH:26][C:25]4[C:20](=[CH:21][CH:22]=[C:23]([OH:28])[CH:24]=4)[CH:19]=3)[CH2:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 199620861-[4-(3-Trifluoromethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl]-2-(6-methoxy-naphth-2-yl)ethane hydrochloride

Product 1

HCID 199620901-[4-(3-Trifluoromethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl]-2-(6-hydroxy-naphth-2-yl)ethane hydrobromide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 1-[4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl]-2-(6-methoxy-naphth-2-yl)ethane hydrochloride (0.6 g, 0.0013 mol)(obtained as described in Example 3) and 33% HBr in acetic acid (20 ml) is refluxed for 4 hours.

Workup

  1. temperatureis refluxed for 4 hours

Sources & evidence

ORD record
ord-23664479d5a24ab191945229f32de959
Source dataset
uspto-grants-1997_01
Patent number
US05596101

Reaction notes

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